Effect of the peptide of thymic origin (synthetic thymohexine-RKNVYR) on hemopoietic cell progenitors in intact and irradiated animals
OV Semina, TN Semenets, VI Deigin, AM Korotkov… - Immunology letters, 1996 - Elsevier
Thymohexine treatment of intact CFU-S was shown not to change their capacity to form
colonies both in vivo and in vitro. Thymohexine, similarly to thymus cells, increased colony
yield from rabbit antimouse brain antiserum (RAMBS)-treated bone marrow. Combined
treatment with thymohexine and thymocytes did not restore colony formation by RAMB
serum-treated bone marrow. Thymohexine halved the harmful effect of low doses of ionizing
radiation on CFU-S, and, moreover, treatment with the peptide after 4 Gy-irradiation led to …
colonies both in vivo and in vitro. Thymohexine, similarly to thymus cells, increased colony
yield from rabbit antimouse brain antiserum (RAMBS)-treated bone marrow. Combined
treatment with thymohexine and thymocytes did not restore colony formation by RAMB
serum-treated bone marrow. Thymohexine halved the harmful effect of low doses of ionizing
radiation on CFU-S, and, moreover, treatment with the peptide after 4 Gy-irradiation led to …
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